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KMID : 1039620220120030167
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Korean Journal of Family Practice
2022 Volume.12 No. 3 p.167 ~ p.172
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Association between Serum Folic Acid Level and the Risk of Hypertriglyceridemia in Korean Female: Analysis Based on 2016?2018 Korea National Health and Nutrition Examination Survey
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Lee Ji-Yeon
Lee Duk-Chul
Yu Nan-Ie
Lee Hye-Jun
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Abstract
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Background: Serum folic acid is associated with atherosclerosis and dyslipidemia. However, the association between folic acid and triglycerides iscontroversial. Therefore, we aimed to analyze the association between serum folic acid levels and hypertriglyceridemia risk in Korean female.
Methods: We analyzed data of 2,823 female from the 2016?2018 Korean National Health and Nutrition Examination Survey. Serum folic acid levelswere grouped into quartiles, and hypertriglyceridemia was defined as a serum triglyceride level ≥200 mg/dL. We examined the association betweenquartile-categorized serum folic acid levels and hypertriglyceridemia using multivariate logistic regression after adjusting for age, hypertension,diabetes, dyslipidemia, current smoking status, alcohol intake, aerobic exercise, and body mass index.
Results: In the multivariate model, the odds ratio for hypertriglyceridemia in the third quartile (8.00?10.80 ng/mL) of serum folic acid levels wassignificantly lower than that in the first quartile (reference: <5.70 ng/mL).
Conclusion: Higher serum folic acid levels were associated with a lower incidence of hypertriglyceridemia in Korean female. Further prospective studieswith larger sample sizes are needed to confirm a clear causal relationship.
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KEYWORD
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Hypertriglyceridemia, Triglyceride, Serum Folic Acid, Folate, Atherosclerosis, Korean Female
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